Search results for "Preemptive antiviral therapy"

showing 3 items of 3 documents

Efficacy and Safety of a Preemptive Antiviral Therapy Strategy Based on Combined Virological and Immunological Monitoring for Active Cytomegalovirus …

2016

Preemptive antiviral therapy for active CMV infection in allogeneic stem cell transplant recipients guided by immunological and virological parameters minimizes the risk of recurrent viremia in a subset of patients.

0301 basic medicineCongenital cytomegalovirus infectionViremiaContext (language use)DiseaseMajor Articles03 medical and health sciences0302 clinical medicineInterferonImmunityallogeneic stem cell transplantationimmunological monitoringMedicineIFN-γ CD8+ T cellscytomegalovirusbusiness.industryvirus diseasesmedicine.disease030104 developmental biologyInfectious DiseasesOncologypreemptive antiviral therapyImmunologyStem cellbusinessCD8030215 immunologymedicine.drugOpen forum infectious diseases
researchProduct

Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Trans…

2019

The current study evaluates the clinical effect of sirolimus exposure on the occurrence of cytomegalovirus (CMV) DNAemia necessitating preemptive antiviral therapy. A total of 167 consecutive recipients of reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT) who received sirolimus- and tacrolimus-based graft-versus-host disease (GVHD) prophylaxis and whose CMV serostatus was positive for donors and/or recipients were included in this multicenter retrospective study. A parametric model with consecutive sirolimus blood levels describing the time to CMV DNAemia-RAT was developed using NONMEM version 7.4. Overall, 122 of 167 patients (73%) were all…

AdultMaleOncologymedicine.medical_specialtyPremedicationmedicine.medical_treatmentCongenital cytomegalovirus infectionHematopoietic stem cell transplantationAntiviral AgentsAllogeneic hematopoietic stem cells transplantationMechanistic target of rapamycin inhibitorQuantitative PCR03 medical and health sciences0302 clinical medicineTime-to-event analysisInternal medicineHumansTransplantation HomologousMedicineCumulative incidenceCytomegalovirus diseaseSurvival analysisRetrospective StudiesSirolimusTransplantationDose-Response Relationship Drugbusiness.industryHazard ratioHematopoietic Stem Cell TransplantationPK/PDvirus diseasesRetrospective cohort studyHematologyMiddle Agedmedicine.diseaseCytomegalovirus infectionsurgical procedures operativeCytomegalovirus DNAemia030220 oncology & carcinogenesisSirolimusCytomegalovirus InfectionsPreemptive antiviral therapySirolimus exposureFemalebusinessSerostatusImmunosuppressive Agents030215 immunologymedicine.drug
researchProduct

Dynamics of cytomegalovirus (CMV) plasma DNAemia in initial and recurrent episodes of active CMV infection in the allogeneic stem cell transplantatio…

2011

Preemptive antiviral therapy strategies for active cytomegalovirus (CMV) infection occurring in allogeneic stem cell transplant recipients should be optimized to avoid overtreatment. The current study was aimed at determining whether the analysis of the kinetics of CMV DNA load in plasma may provide useful information for the therapeutic management of active CMV infection in this setting. A total of 59 consecutive patients were included in the study, of which 40 (67.8%) developed 1 (n = 21) or more (n = 19) episodes of CMV DNAemia. The need for antiviral therapy for initial or secondary episodes of CMV DNAemia could not be predicted on the basis of the CMV DNA load value in the first plasma…

AdultMaleAdolescentCongenital cytomegalovirus infectionCytomegalovirusAntiviral Agentslaw.inventionYoung AdultlawMedicineDoubling timeHumansTransplantation HomologousKinetics of CMV DNA load declineYoung adultPolymerase chain reactionAgedTransplantationbusiness.industryAntiviral therapyHematopoietic Stem Cell Transplantationvirus diseasesSelf-resolving episodes of active CMV infectionHematologyMiddle Agedmedicine.diseaseCMV doubling timeCMV DNA load in plasmaClinical trialTransplantationImmunologyPreemptive antiviral therapyCytomegalovirus InfectionsDNA ViralFemaleStem cellCytomegalovirus (CMV)businessBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
researchProduct